January 1, 2014 - Partners on Validation of Mobile Cognitive Apps for building “Virtual Research Cohorts”

The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials:

Dorene M. Rentz, PsyD1,5, Maria Dekhtyar2, Julia Sherman3, Deborah Blacker, MD, ScD4, Rebecca E. Amariglio, PhD5, Kathryn V. Papp, PhD5, Adrian Schembri, DPsych6, Tanya Chenhall, MA6, Paul Maruff, PhD6, Paul Aisen, MD7, Reisa A. Sperling, MD1,5 and Bradley T. Hyman, MD, PhD1

Validation of CogState on iPads for Self-Administration:

  • From a clinical trial perspective, self-administered cognitive tests would greatly reduce the burden of in-clinic visits and enable participation of individuals residing anywhere and everywhere
  • Self-administration would also allow for multiple assessments within a shorter timeframe, potentially increasing the reliability of cognitive endpoints that can translate into a more sensitive measurement of change over time
  • More importantly, self-assessments could also promote the rapid evaluation and feedback on “brain health” among individuals in the community, empowering them to seek care, change behaviors or become involved in research